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When LOOH is overloaded or GPX4 is absent or dysfunctional, Fe 2+ reacts with LOOH, generating toxic lipid peroxidation, thereby triggering ferroptosis

P., Mazur, D

Tournu G, Abramowitz L, Couffignal C, Juguet F, Snjoux A, et al (2017) Prevalence of anal symptoms in general practice: a prospective study

On the basis for such association might be altered cerebral hemodynamics with loss of cerebral autoregulation, higher arterial stiffness, and increased speed and pulsatility of flow in small vessels (arterioles and capillaries)

du Preez, H

But because there arent published human clinical trials on KPV, we simply dont yet know how this translates to humans, what dosing ranges are best, or whether it's safe over the long term