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And while from the outside it may seem like its not the worst thing to happen, it can set the stage for some pretty nasty health issues, including type 2 diabetes, obesity, metabolic syndrome, cardiovascular disease, NAFLD, PCOS, and more 12

PPAT transfers glutamine-derived nitrogen to 5-phosphoribosyl pyrophosphate (PRPP), and this step is considered the initial step in purine biosynthesis 37