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The difference is not always body weight, and it is not always straightforward

Phase 2 NEJM titration (still common in research) Phase 2 retatrutide titration schedule Phase Initiation Weeks Weeks 1-4 Weekly Dose 1 mg Phase Early escalation Weeks Weeks 5-8 Weekly Dose 2 mg Phase Mid escalation Weeks Weeks 9-12 Weekly Dose 4 mg Phase High escalation Weeks Weeks 13-16 Weekly Dose 8 mg Phase Maximum Weeks Weeks 17+ Weekly Dose 12 mg Source: Jastreboff et al., NEJM 2023

Do not use GLP-1 treatments if: Warnings and Precautions: Pregnancy and Reproductive Health: GLP-1 medications may cause harm to a fetus and should not be used during pregnancy or when planning to become pregnant

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The safety profile of dual agonists is similar to pure GLP-1 agonists, with the main difference being slightly higher rates of GI side effects

As a modified C-terminal fragment of human growth hormone (hGH fragment 177-191), this peptide is highly sought after in metabolic and lipolytic research models