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Blocking the cytokine-mediated inflammatory cell death signaling pathway may benefit patients with COVID-19 or other infectious diseases by limiting tissue damage ( Figure 1 Implications on Antibacterial and Antiviral Immunity According to in vitro studies, TNF- facilitates the SARS-CoV interaction with angiotensin-converting enzyme 2 (ACE2) ( Nuclear factor kappa B (NF-B), a transcription factor modulating both innate and adaptive immunity, is also crucial in the progress of COVID-19 (Figure 2)

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All-trans retinoic acid (ATRA), the active form of vitamin A, binds to nuclear retinoic acid receptors (RAR//), regulating various biological processes, such as cell proliferation, differentiation, and apoptosis ( 3.2 Vitamin D Vitamin D, or calciferol, is a fat-soluble vitamin essential for calcium homeostasis and bone health