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Fujigaki H, Yamamoto Y, Saito K (2017) L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences

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Activated IRS-1 recruits and activates phosphoinositide 3-kinase (PI3K), resulting in phosphatidylinositol 3,4,5-trisphosphate (PIP3) generation at the plasma membrane