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Gaps widen when other studies fold dietary supplements into prescription totals, hold list prices static despite rapid net erosion, or extrapolate U.S

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However, for individuals actively managing complex, reactive chronic illnesses like Long COVID, ME/CFS, or severe dysautonomia, such high starting doses are rarely recommended due to the high potential for gastrointestinal upset or rapid, uncomfortable detoxification reactions (often referred to as a Herxheimer reaction)