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However, DPP-4is are still commonly prescribed in patients with T2D and atherosclerotic cardiovascular disease (ASCVD)

Moderate cardio of 2-3 sessions weekly at low to moderate intensity supports cardiovascular health, aids recovery between lifting sessions, and contributes to overall caloric expenditure without significantly impacting muscle building

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While semaglutide itself does not appear to cause liver damage, ongoing alcohol use can complicate the clinical picture and increase the risk of hepatotoxicity from multiple sources

Even then, oral bioavailability remains low, around 0.4-1%, requiring much higher doses than injectable forms

Mar M, Morales A, Colell A, Garca-Ruiz C, Fernndez-Checa JC