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In positions P +4 and P +6 at the C-terminal side of the P 0 position, two glycine residues (G759 and G761) are positioned such that their amide protons can form interactions with the phosphorylated side chain of T595 within the CDK11 T-loop (Supplementary Fig

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Furthermore, the broader implications of these interactions for patient management, including the timing of dosing and monitoring of therapeutic outcomes, highlight the need for a nuanced approach

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