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Melatonin decreases apoptosis and expression of apoptosis-associated proteins in acute puromycin aminonucleoside nephrosis

This epigenetic silencing effectively inhibits class-switch DNA recombination (CSR), somatic hypermutation (SHM), and plasma cell differentiation, thereby reducing the production of both T-dependent and T-independent autoantibodies (e.g., anti-dsDNA antibodies)

The two 2006 pharmacokinetic studies are the main human evidence

It is renowned for its anti-aging properties, which can help to improve skin tone, by reducing wrinkles and dark spots and increasing elasticity

Dig Dis Sci 57(12):31263135