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The combination of oxidative stress caused by H 2 O 2 , along with H 2 S led to the formation of persulfides, detected as CAM-S-CAM-TPP or as GSS-CAM-TPP, while H 2 O 2 or H 2 S alone did not (Fig

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Similarly, recruitment of participants with severe hepatic impairment into the hepatic impairment study was challenging and, despite a third study site being added and the recruitment period being prolonged, it was not possible to complete recruitment of seven participants into the severe hepatic impairment group