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[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Abdel Raheem A, Rushwan N, Garaffa G, Zacharakis E, Doshi A, Heath C, et al

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On top of understanding the microbial pathogenesis and the molecular and cellular mechanisms of disease biology, activity of a therapeutic agent in a translational research, be it either in vitro or in vivo, is critical to proffer advancement to first-in-human clinical trials based on laboratory findings of pharmacology, toxicology, and immunology