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When determining if some molecule would behave as anti or prooxidant of particular importance are micro-conditions (pH, presence of trace metals, etc.) restricted for specific cell compartment

a patent, Smith, U.S

Here, Ekihiro Seki & team implicate the fungal sensing adaptor protein CARD9 in maintaining gut barrier integrity under metabolic stress, finding that the loss of fungal sensing exacerbates liver injury in a murine model of MASLD

the bulky 2-naphthyl side chain is essential for potency and selectivity D-Phenylalanine (position 4):Contributes to metabolic stability and receptor-binding specificity

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