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Stress, fatigue and 'brain fog' as well as reduced physical stamina are common side effects of Vitamin B12 deficiency

Blankenberg S, Rupprecht HJ, Bickel C, Torzewski M, Hafner G, Tiret L, Lackner KJ

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Conclusion Two thirds of an unselected group of ME/CFS patients treated for 3 months with vitamin B12 nasal drops had a favorable outcome in objective measures and subjective patient reported outcome, which were associated with a significant increase in serum vitamin B12 levels

And understanding these factors helps you optimize your treatment and achieve the best possible results