When the heart is ruled out and no clear cause is found, the pain is labeled non-specific
[7] An editorial in SAMJ notably highlighted obesity as a new epidemic in Southern Africa
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Colonic biopsies from these patients also show reduced GLP-1R expression, suggesting that decreased GLP-1 and GLP-1R expression may underlie the efficacy of ROSE-010 in alleviating IBS-C abdominal pain [61]
