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Srebp-controlled glucose metabolism is essential for NK cell functional responses

The cagrilintide and semaglutide combination (CagriSema) demonstrated this clearly, with the combination exceeding the sum of individual effects

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Mol Immunol

As fasting increases ketone production with a concomitant increase in CYP2E1 activity, this in turn increases the production of NAPQI and decreases amino acid substrates for GSH production