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Incorporate candidate bile acid/indole metabolite supplementation or receptor/pathway antagonism into the ABX + FMT foundation to form the shortest closed loop of Key MoleculeKey Receptor/PathwayKey Phenotype. Standardize reporting of metabolomics platforms, sample sources, and threshold strategies, and conduct sensitivity analyses/stratified interpretations for items with inconsistent directionality to enhance reproducibility and cross-study comparability

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Ciancarelli, I., Tozzi-Ciancarelli, M., Spacca, G., Massimo, C