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However, human pharmacokinetic data is not published, so oral bioavailability in humans is not confirmed

Yet, there is no gold standard blood test, and the manifestation of clinical symptoms is important in the diagnosis of vitamin B 12 deficiency (13)

The use of hydroxocobalamin became first line due to its low adverse risk profile, rapid onset of action, and ease of use in the prehospital setting

These analytical measures support reproducibility, consistency, and confidence across independent laboratory investigations

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