doi:10.1001/jamaneurol.2018.4304 229
A published real-world study (Advances in Therapy, 2025) documented mean weight loss of 14.1% for semaglutide and 16.5% for tirzepatide over one year in nearly 10,000 patients on FDA-approved formulations - these research figures are not specific to compounded programs or to WellMedr
Learn more about the FDA's work fighting counterfeit and illegally compounded weight loss injectables
Many of these gastrointestinal claims have been consolidated into a federal MDL, which is accepting new cases
For context on the broader compounded versus brand-name comparison, our guide on compounded semaglutide storage covers handling differences, and the article about how long compounded semaglutide lasts in the fridge addresses stability concerns that can also affect potency and dosing accuracy
The distinction between compounded and FDA-approved products - and what each designation means for safety, efficacy, and quality oversight - is worth understanding before enrolling in any program