The diagnosis of acute pancreatitis required two of the following three features: abdominal pain consistent with acute pancreatitis, serum lipase and/or amylase activity at least three times greater than the upper limit of normal, and imaging findings characteristic of acute pancreatitis
Patients with BBS also demonstrate severe early-onset obesity and hyperphagia, thought to be due in part to defective MC4R signaling
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The results immediately revealed the value of screening pairs of knockouts across different metabolic conditions
