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As of July 1, 2025, many Aetna standard commercial plans removed Zepbound from their formularies when prescribed for the purpose of weight management

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However, previous studies have not investigated GLP-1 analogs and exendin 939 for pain transmission at peripheral sites, especially in small-sized nociceptive DRG neurons, where the TRPV1 channel is crucial in chronic pain-induced mechanical allodynia and thermal hyperalgesia 58,59,60,61