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In mouse models of Alzheimers disease, triple agonists play a neuroprotective role and ameliorate cognitive deficits by significantly reducing hippocampal amyloid-, phosphorylated tau aggregates, and neuroinflammation, and stimulating neurogenesis and brain-derived neurotrophic factor expression (Li et al., 2018

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Evidence suggests that, in addition to uterine cells, trophoblasts also produce ECM components like laminin, fibronectin, and vitronectin to increase their production of MMP, which is necessary for their invasion in an autocrine manner (44)

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Researchers first identified it decades ago and later discovered that levels tend to decline with age

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