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As shown, for instance, by Visser et al

Call your health care provider immediately if you are experiencing any signs of an allergic reaction: skin rash, itching or hives, swelling of the face, lips, or tongue, blue tint to skin, chest tightness, pain, difficulty breathing, wheezing, dizziness, red, swollen painful area on the leg

While more research is needed, the current evidence supports B12 as a treatment for nerve pain

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However, later work showed comparable membrane potential-dependent transport of Spd and Spm in glia, and similar transport more specific for Spm in neuronal synapses (Masuko et al., 2003)