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The company describes retatrutide as an investigational once-weekly triple-hormone receptor agonist that activates GIP, GLP-1, and glucagon receptors with a single molecule.[4] This development history is important because retatrutide was designed as a next-generation incretin therapy rather than as a simple modification of an existing GLP-1 agent

The greater the weight loss potential, the more significant the levothyroxine dose adjustments will need to be

The pharmacological effects begin immediately, but visible results take time

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