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A 6-h treatment with thioacetamide led to a significant increase in ROS levels compared with the control group, but pre-treatment with 2APB effectively mitigated this oxidative stress in the liver of both wild-type and hepsin / mice

They possess antioxidant and anti-inflammatory properties, and their chemical structure allows them to scavenge several types of free radicals

Cells were incubated with QIs or parent compounds for 2.5 h, based on the time-dependency of QIs-induced loss of cell viability (Supplementary Figure S3)

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For each transformation, three positive colonies were picked randomly for further investigation