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Some common scenarios: Upgrading from semaglutide to tirzepatide: If youve plateaued on semaglutide or want to enhance results Trying semaglutide first: Some patients start with semaglutide and achieve their goals without needing to switch Managing side effects: If one medication causes intolerable side effects, the other may be better tolerated Switching medications requires medical supervision to ensure proper dosing and minimize side effects

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Most recently, in October 2024, an updated ASA-led multisociety clinical practice guidance shifted toward a risk-stratified approach, highlighting prolonged fasting and optional POCUS evaluation rather than universal discontinuation of GLP-1 RAs [10]

Helps improve physical performance when used in conjunction with a training regimen

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Patients were predominantly female and white