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Patients were assumed to continue basal insulin therapy (plus concomitant metformin with or without an SGLT-2 inhibitor) for the remainder of their lifetimes, with HbA1c continuing to follow the UKPDS 90 progression equation

X-ray crystallography revealed how DPP-4 cleaves a tripeptide substrate (Ile-Pro-Ile), known as Diprotin-A (PDB ID 1nu8

Mechanism: Both stimulate growth hormone release, but the DAC version has a longer half-life, allowing for less frequent dosing

Additionally, catalase concentrations did not show significant changes in the groups treated with DXN, TIR, or their combination (Figure 6)

Dose 4.5 mg = 1.8 ml, exceeds a 1 ml syringe, requires a 2 ml syringe or two injections