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SLE patients with active symptoms are found to have a higher proportion of Th17 cells and serum IL-17 levels compared to the healthy controls, and Th17 lymphocyte numbers are positively correlated with SLE disease activity and severity (53)

They were generally described as mild to moderate in severity and transient in nature

The 12 mg dose escalation group achieved a 2.02% reduction in HbA1c at 24 weeks, along with 16.94% body weight loss at 36 weeks

PubMed Central (PMC)

To ensure the best results, treatment plans should be tailored to the specific needs of individual patients, considering their ethnic backgrounds and socio-economic conditions, among other factors

Persistent hyperglycemia and metabolic dysregulation promote oxidative stress, reduce nitric oxide bioavailability, and activate inflammatory pathways, thereby accelerating atherosclerosis and cardiovascular complications