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An earlier 12-week trial in 300 obese adults produced a genuine positive signal the 1 mg daily dosing arm showed a statistically significant 2.8 kg mean weight loss versus 0.8 kg in the placebo group and that result is what justified moving into the larger Phase IIb trial

Retatrutide is an investigational peptide drug developed by Eli Lilly that acts as a triple agonist, simultaneously targeting three hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

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-(as riboflavin-5'-phosphate)