High doses of the anti-rheumatic drug auranofin have been shown to activate ferroptosis by inhibiting TXNRD1 activity [55]
Indeed, using BODIPY 493/503 staining to detect neutral lipids, we observed that ascites treatments increased lipid droplet contents as observed using confocal microscopy (Fig
In an extended review, it was highlighted that some preclinical gene-therapy approaches delivering exogenous antioxidant enzymes, via viral vectors or nanozyme platforms, in animal models of hyperglycemic bone defects, significantly reduced inflammation, limited ROS-mediated damage, and improved healing outcomes (Li et al., 2024)
Novel locally active estrogens accelerate cutaneous wound healing
in an experimental setting, such cancers were sensitive to upstream activation by insulin and IGF-1, and regressed during CR
Moreover, the floral extract and the polyphenol fraction exhibit significant anti-inflammatory properties as they suppressed cytokine release (IL-6, TNF-, IL-8) from HCE-T and human acute monocytic leukemia cell lines (THP-1) and the activity of NF-B and calcium influx in THP-1 and Jurkat cells were diminished
