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Tirzepatide is a single molecule that activates both the GIP and GLP-1 receptors

It includes: Vitamin C: Supports the immune system and combats oxidative stress

doi: 10.1111/bph.70145

In chronic metabolic states like obesity and T2DM, the GLP-1R signaling axis undergoes significant alterations that drive incretin resistance and impaired glucose control (Rabbani and Thornalley, 2024

The 3 mg dosage serves as the initial dose in the treatment regimen, helping patients transition effectively to higher maintenance doses

Although MVMR was conducted to account for potential confounding by BMI and T2DM, several methodological limitations precluded its reliable interpretation