This is not the same as FDA-approved use, but it may allow eligible patients to begin their weight loss journey today
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Importantly, the weight-reducing efficacy appears comparable to that observed in common, polygenic obesity, as preliminarily evidenced by subgroup analyses from large trials such as SURMOUNT-1
External resources New England Journal of Medicine: Retatrutide Phase 2 Trial for Obesity PMC: Comparative Efficacy of Tirzepatide vs Retatrutide Network Meta-Analysis Nature Medicine: Retatrutide for Metabolic Dysfunction-Associated Steatotic Liver Disease U.S
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Our experiment aims to clarify the mechanism of berberine promoting the secretion of GLP-1 in intestinal L cell and islet cell, activating GLP-1R and its downstream molecules through endocrine and paracrine ways, thus improving the function of islet cell and treating T2DM