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In contrast, over the last two decades many studies have implicated the IGF-1 system in the development of several malignancies including breast cancer

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The first paper found that across many clinical trials (largely focused on semaglutide), women lost a higher percentage of weight than men (~11% for women, ~7% for men)

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Moving forward, a combination of targeted metabolic inhibitors, engineered immune therapies, and bioinformatics-guided treatment strategies offers substantial potential for disrupting CSC-driven tumor progression and improving long-term patient outcomes