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It enables oxidation by dissolving oxygen that attacks vulnerable residues like methionine and cysteine

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Tirzepatide may be better for patients who have not seen success with other programs, who have insulin resistance, or who want to pursue more aggressive weight loss goals

Around the same time, I think you remember that all of pharma was interested in obesity in the early 90s, everyone wanted to do diabetes as well as obesity, but they were separate teams and they all wanted to do small molecules, but it just happens to be so that the best idea we could find at that time was actually GLP-1, because we actually had clinical data relatively early that GLP-1 was a really good candidate as a treatment for diabetes because of the glucose sensitivity of the actions

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