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A computer modeling study suggested that lipoic acid might bind to the intracellular tyrosine kinase domain of the insulin receptor and stabilize the active form of the enzyme (43)

[DOI] [PubMed] [Google Scholar] 146.Kanhai K.M.S., Zuiker R.G.J.A., Stavrakaki I., Gladdines W., Gaillard P.J., Klaassen E.S., Groeneveld G.J

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It activates several overlapping pathways, notably VEGFR2 and nitric oxide synthesis via the Akt-eNOS axis, promoting angiogenesis, fibroblast activity, and neuromuscular stabilization

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