does glp 1 improve mood The GLP-1 semaglutide (#Ozempic) failed to and executive functioning in this, the first RCT of a GLP-1 for major #depression: Dynamic GLP1 - GLP-1 Supplement

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The discrepancy could be due to the difference in cell models and the high rapamycin concentration (100 nM) used in that study which may have induced cell stress 24

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Early findings suggest these medications could affect inflammation, mitochondrial function, and neuronal survival pathways

This altered baseline metabolic context could modulate the host response to GLP-1 receptor agonist therapy, which has itself been associated with microbial remodeling and shifts in gut-derived signaling metabolites (81)