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Impairment of glutathione function in the brain is linked to loss of neurons during aging and to neurological diseases including Parkinson's disease and Alzheimer's disease
Senile plaques (extracellular depositions) and neuronal tangles (intracellular accumulation of misphosphorylated tau protein), are the main histopathological hallmarks of the AD, critical for post-mortem diagnosis
Consequently, sarcopenia, characterized by loss of muscle mass and strength, is a robust biomarker for CHE and OHE [44,45,46]
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