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The observed interactions between the ECD and ECL1/3 in the inactive GLP-1R structure presented here agree with previous studies suggesting that the ECD stabilized an inactive state of the glucagon receptor through interactions with ECL1 and ECL3 20
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This accelerates age-related sarcopenia and may slow metabolism, making weight regain more likely after stopping medication
Funding Open access funding provided by Universit degli Studi di Roma La Sapienza within the CRUI-CARE Agreement
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