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However, these compounds are associated with Nrf-2-independent adverse effects, which prevented their clinical use despite their beneficial induction of glutathione synthesis

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Drug Therapy Numerous drugs and their associated components can also directly attenuate the function of the intestinal barrier and lead to an increased risk of luminal contents entering the systemic circulation

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77 Administration of oral L-Cysteine to patients with cirrhosis has been noted to cause a twofold greater maximal plasma cysteine concentration and plasma elimination half-life, and a delayed excretion of metabolic end products when compared with those of controls