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He added that the last study on this was 30 years old

The Effects of Long-Term Oral Benfotiamine Supplementation on Peripheral Nerve Function and Inflammatory Markers in Patients With Type 1 Diabetes: A 24-month, double-blind, randomized, placebo-controlled trial

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doi: 10.12688/f1000research 267 FenouilletEVigourouxASteinbergJGChagvardieffARetornazFGuieuRet al

5-Amino-1MQ is a small-molecule quinolinium compound not a peptide that selectively inhibits nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme involved in the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor

The number of animals was limited, and the experiments came from a small group of collaborating investigators