Gastrointestinal side effects represent one of the most common challenges when starting GLP-1 receptor agonist therapy, with diarrhea occurring in approximately one-quarter of patients during initial dose escalation
Small notes that some state programs cover GLP-1 medications for weight management, while others dont cover any weight loss drugs at all
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However, most evidence comes from in vitro studies and animal models rather than controlled human trials in rheumatoid arthritis
Approved by the FDA in October 2006, and branded as Januvia, the drug soon became one of Merck's most successful drugs
These letters addressed concerns including misleading advertising, quality control issues, and compliance failures