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10.1038/s41598-017-11555-9 14 MaS.RenN.HuangQ

In patients in whom the major therapeutic goal is the compelling need to minimize the therapeutic risk pf hypoglycaemia, DPP-4 inhibitors are recommended as second line therapy after metformin failure at the same level as second line treatment options with GLP-1 receptor agonists, SGLT-2 inhibitors, or TZDs

However, more extensive studies must be conducted to confirm its long-term impact

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