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Notably, NDV, classified as an oncolytic virus, exploits ferroptosis as an antitumor mechanism by promoting E3 ubiquitin ligase parkin (PRKN)-mediated ubiquitination and degradation of Yes-associated protein (YAP) at Lysine 90 (Lys90) while concurrently activating the p53/SLC7A11/GPX4 pathway, thereby intensifying ferroptosis in tumor cells (Sun et al., 2024)

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