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Mechanistically, impaired iron exporte.g., zinc-mediated inhibition of amyloid precursor protein (APP) ferroxidase activityprovides a route to local iron accumulation (Duce et al., 2010), while familial AD presenilin mutations confer selective vulnerability to ferroptosis in human neuronal models (Greenough et al., 2022)

2 GLP-1-based therapies, including GLP-1 receptor agonists (GLP-1RA), have shown considerable efficacy in the management of DM2 and obesity

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the CRA accepts paid pharmacy printouts as supporting documents