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Several natural compounds have been proposed as interventions for PD including coenzyme Q10, curcumin, resveratrol and omega-3 fatty acids, however these agents have shown limited clinical efficacy, often failing to produce measurable changes in Unified Parkinsons Disease Rating Scale (UPDRS) outcomes or biomarkers of oxidative stress

High blood sugar levels due to poor insulin use (high glucose levels) can damage endothelial cells the cells lining blood vessels, lymphatic vessels, and organs and cause oxidative stress

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