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Description

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Fatty infiltration of the pancreas promotes impaired pancreatic -cell function and gradual hyperglycemia, which will further enhance de novo hepatic lipogenesis and promote higher NEFAs levels to the circulation (the twin cycle hypothesis) [18]

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Hallmark pathways such as oxidative phosphorylation, glycolysis, fatty acid metabolism, MYC targets V1, adipogenesis, and bile acid metabolism were significantly upregulated in tumors from mice subjected to RETA-w/d (Fig

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