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Both were published in the New England Journal of Medicine in mid-2025

Second, it is given SC, IM or orally weekly injections or daily capsules, titrated to serum cobalamin but not intravenously

Injection Site and Contamination Risks Subcutaneous injection technique matters

Longevity and wellness: Improved sleep and hormonal balance may support anti-aging and overall wellness strategies

Routine supplementation in someone who is iron-replete can drive ferritin into overload territory within months particularly in men, postmenopausal women, and people with undiagnosed HFE mutations