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Our findings suggest that GLP-1R/GCGR dual-agonists provide benefits to patients with obesity, T2D and MASH and can likely be quite effective in preventing T2D progression in patients with prediabetes, especially if also exhibiting hepatic steatosis
These analytical procedures ensure traceability, purity verification and laboratory-grade compound consistency
Importantly, when researchers blocked the GLP-1 receptor by injecting its inhibitor into the joint, the protective effects disappeared
However, clinical studies indicated that GLP-1 treatment had little effect on hepatic steatosis in some NAFLD patients, suggesting that GLP-1 resistance may occur in these patients