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A Phase 1 Study of Milademetan in Combination With Quizartinib in Patients With Newly Diagnosed (ND) or Relapsed/Refractory (R/R) FLT3-ITD Acute Myeloid Leukemia (AML)
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Experimental studies suggest that Mn excess promotes hepatic steatosis through oxidative stress and insulin resistance, while Mn deficiency impairs mitochondrial antioxidant defense and lipid metabolism (Hu et al., 2025
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