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Hepsin is crucial in protecting against APAP-induced liver injury by regulating gap junctions and reducing oxidative stress

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GPx1 (/) mouse fibroblasts showed a decrease in protein kinase B (Akt) phosphorylation at Ser-473 during stimulation with hydrogen peroxide, while GPx1-under-expressed MCF-7 cells did not affect the expression and phosphorylation of p38 MAPK [52]

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Evidently, all of the above sources of acetate can be moderated by voluntary dietary choices for the purpose of cancer management (considering that acetate promotes lipid synthesis in tumors under hypoxia 272 ), especially by avoiding alcohol that has been firmly linked to neoplasia 273

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Digested peptide samples were desalted using in-house packed C18 (3M) StageTips

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