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Cost Concerns The high cost of GLP-1 drugs, especially for weight loss purposes, is another driving factor behind the microdosing trend

Suspected side effects should be reported to the MHRA Yellow Card scheme in addition to informing the clinical trial team

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10 Many misrepresent the naturally occurring GLP-1 hormone with GLP-1 RA

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demonstrated that the GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant Apoe/Irs2+/ mice by promoting macrophage polarization towards an anti-inflammatory M2 phenotype, which was associated with enhanced plaque stability (i.e., thicker fibrous caps, fewer necrotic cores, and decreased inflammatory infiltrates)